Study participants were male (147/374) and female (227/374) adult outpatients, aged 18-65 years, meeting DSM IV-TR criteria for GAD. Briefly, patients were randomized to 8 weeks of flexible-dose treatment with pregabalin (300-600 mg/day), venlafaxine XR (75-225 mg/day) or placebo. The full methodology and results of this trial have been described elsewhere 22. The primary endpoint in the study was anxiety symptom change, measured by Hamilton Anxiety Rating Scale (HAM-A) total score, from baseline to the last post-randomization visit prior to dose tapering. Using a statistical mediation model, we further sought to ascertain the extent to which pregabalin's effect on sleep disturbance is attributable to a direct effect of the drug, as well as an indirect effect mediated through anxiety symptoms.ĭata were obtained from a randomized, double-blind, flexible-dose, parallel-group, placebo- and active-controlled study in 394 patients with GAD. In this study, we fully describe the effects of pregabalin on sleep and further characterize the beneficial effects of pregabalin on frequency and intensity of sleep disturbances in GAD. In healthy volunteers, it increases slow-wave sleep as a proportion of both the total sleep period and the duration of stage 4 sleep, and reduces the number of awakenings of more than 1 minute in duration 21.Ī recent trial of pregabalin in GAD 22 included subjective assessment of sleep using the Medical Outcomes Study Sleep Scale (MOS-SS). It has also demonstrated substantial beneficial effects on sleep. Pregabalin, a ligand for the a 2 d subunit of voltage-gated calcium channels, has been shown to effectively reduce the symptoms of GAD 18-20. Insomnia rates reported with the serotonin-norepinephrine reuptake inhibitors (SNRIs) duloxetine and venlafaxine appear to be similar to those reported for SSRIs 16,17. It is well established that insomnia is reported as an adverse event with many SSRIs - across anxiety and depression indications, insomnia rates are 9-28% 12-15. There are strong indications that SSRIs might also have sleep-disrupting effects in patients with GAD. SSRIs have also been reported to reduce the latency and duration of rapid eye movement sleep 11. In healthy volunteers, SSRIs, such as paroxetine and fluvoxamine, reduce sleep efficiency and increase the number of awakenings and sleep onset latency 10. While benzodiazepines appear to improve measures of sleep onset and/or sleep maintenance 9, selective serotonin reuptake inhibitors (SSRIs) tend to have a disruptive effect on sleep. Polysomnography studies in patients with GAD have revealed sleep abnormalities including problems with sleep latency, early morning insomnia, decrease in total sleep time, and sleep architecture 5,6.Įpidemiological surveys in primary care have further highlighted that alongside pain, sleep disturbances are the most frequent presenting complaints of patients with GAD and have a strong negative impact on anxiety symptoms and patient functioning 7,8.ĭifferent classes of agents used for the treatment of GAD have different effects on sleep. The mediation model indicated that 53% of the total pregabalin effect on sleep disturbance was direct (p 65 years) 4. Venlafaxine XR (n = 125) had no significant effect on these measures. Results: Compared with placebo (n = 128), treatment with pregabalin (n = 121) significantly reduced scores on the sleep disturbance subscale and Sleep Problems Index II at both week 4 and week 8, and the sleep adequacy subscale at week 8. A mediation model was used to estimate separately for both treatment arms the direct and indirect treatment effects on sleep disturbance. Anxiety symptoms were assessed with the Hamilton Anxiety Rating Scale. Treatment effect on sleep was evaluated using the Medical Outcomes Study Sleep Scale. Patients received pregabalin 300 mg/day, venlafaxine XR 75 mg/day or placebo for a week, followed by pregabalin 300-600 mg/day, venlafaxine XR 75-225 mg/day, or placebo for 7 weeks. Methods: A post-hoc analysis of data from a randomized, double-blind, placebo- and active-controlled study in patients with GAD was conducted. Germanyīackground and Objectives: To characterize the impact of pregabalin on sleep in patients with generalized anxiety disorder (GAD) and to determine whether the impact is a direct or an indirect effect, mediated through the reduction of anxiety symptoms. ** Pfizer Inc, Global Research and Development, New London. * Novartis Pharmaceuticals Corporation, Florham Park, New Jersey Cappelleri** Chwen-Cheng Chen** Douglas Feltner** Hans-Ulrich Wittchen*** Pregabalin reduces sleep disturbance in patients with generalized anxiety disorder via both direct and indirect mechanisms
0 Comments
Born into an Italian-American family in Chicag. Following a brief break, Patton and company returned to the stage to close out the evening with a blissful cover of Timi Yuro’s “Satan Never Sleeps,” followed by a robust rendition of Sepultura’s “Territory. Rosemarie Timotea Aurro Yuro, 4 August 1940, Chicago, Illinois, USA, d. The rendition concluded with a playful nod as they briefly weaved in the Pepto-Bismol jingle, followed by a whimsical, flatulent-sounding guitar tone courtesy of guitarist Scott Ian. The band leaned heavily on their The Raging Wrath of the Easter Bunny Demo material during their performance, adding songs “Eracist,” “Glutton for Punishment,” “Anarchy Up Your Anus,” “Methematics,” “Spreading the Thighs of Death,” and “Raping Your Mind” to the evening’s agenda.Īnother standout moment of the evening was the band’s performance of “My Ass Is on Fire” off their 1991 self-titled debut studio album, which ignited an instant frenzy among the crowd. Discover Explore All Trending Releases List Explorer Advanced Search Contribute. The band sounded fierce live, magnified by Lombardo’s powerful thumping and Ian’s masterful guitar craftsmanship. View credits, reviews, tracks and shop for the Vinyl release of 'Collection 18 Greatest Hits' on Discogs. TIMI YURO Vinyl Records and CDs Artist, Title Timi Yuro 16 Unforgetable Ballads Timi Yuro, 18 Greatest Hits Timi Yuro 18 Heartbreaking Song All Alone. Spruance demonstrated guitar wizardry with his versatile and cutthroat playing, complemented by Dunn’s booming bass lines. The mask eventually came flying off and the band’s performance intensified as they unleashed a slew of cover tunes, igniting mosh pits across the floor with their renditions of “I’m Not in Love” (10cc), “Just Sit There” (Crumbsuckers), “Hell Awaits” (Slayer), “You Lose” (7Seconds), and “I Don’t Need Society” (D.R.I.), while they slowed things down for a moment with “True” (Spandau Ballet). Patton took to the stage wearing a black surgical face mask, adorned with a strategically placed zipper opening for effortless access to his powerful vocal spewing. The band ravaged the stage with heavy thrashers “Grizzly Adams,” “Sudden Death,” “Hypocrites / Habla Español O Muere” (their Stormtroopers of Death cover), and “Bungle Grind,” taking the audience back to the early days of the band. The 19-song set kicked off with an explosive barrage of tracks hailing off their The Raging Wrath of the Easter Bunny Demo, a re-recording of their first self-released demo tape of the same name from 1986. This marked their second appearance in the city in recent years, having graced Brooklyn with their presence in early 2020 as part of a limited run of dates featuring their The Raging Wrath of the Easter Bunny Demo lineup. The band returned to New York City on Friday night (September 8th), where they delivered an energetic performance at Terminal 5 in Hell’s Kitchen. Bungle - led by legendary singer Mike Patton and showcasing original members Trey Spruance and Trevor Dunn, along with guitarist Scott Ian (Anthrax) and drummer Dave Lombardo (Misfits, ex-Slayer) - are currently embarked on their first eastern North American tour in 23 years. Nobel acquired a vast fortune from this invention, which spawned an intricate network of factories, sales representatives, and distributors in several industrialized countries around the world. Virtually overnight, dynamite revolutionized the mining industry, for it wasfive times as powerful as gunpowder, relatively easy to produce, and reasonably safe to use. When saturated with nitroglycerine, this porous clay became a highly desirable explosive, whichNobel termed dynamite and patented in 1867. After exhaustive experimentation, Nobel found a nearly perfect substance, kieselguhr. The result was Nobel's first important invention, the mercury fulminate cap.Ī fatal factory accident the following year, in which Nobel's brother Emil was killed, led the inventor to continue his research with nitroglycerine, thistime in the hope of discovering a benign substance to absorb the liquid explosive, thereby making it safe for manipulation and transportation, without seriously diminishing its eruptive characteristics. In Nobel's mind, all that remained was to devise a special blasting charge to ensure a predictable detonation of the nitroglycerine by shock rather than heat, which he already knew tobe a dangerously imperfect firing method. Sharing his interest, his father during this same time designed a method for the large-scale production of the explosive. Through his own studies and experiments, begun as early as 1859, Nobel had familiarized himself with Sobrero's compound of glycerine treated with nitric acid, and had even exploded small quantities of it under water. Instead, gunpowder and guncotton dominated the explosives industry, despite their own shortcomings. After extensive travels, through which he acquired the sharp skills of a businessman andthe distinct advantages of a multilinguist, Nobel returned to Sweden in 1863for the singular purpose of safely manufacturing nitroglycerin.Īlmost two decades earlier, Ascanio Sobrero (1812-1888) had invented this oily liquid, but it proved so volatile as to preclude its widespread use. Like his father, a manufacturer of mines and other explosives, Nobel displayed an avid interest in engineering and chemistry andas a young man worked for a time in the laboratory of French chemist Théophile Jules Pelouze (1807-1867), who is regarded by some as the inventor of guncotton (most accord the honor to Christian Schönbein). Owner of more than 350 patented inventions during his lifetime, Nobel is bestknown as the discoverer of dynamite and the man who upon his death bequeathed much of his large estate to support the annual Nobel Prizes for accomplishments in physics, chemistry, economics, science and medicine, literature, andthe promotion of peace.īorn in Stockholm, Nobel received his education from private tutors and fromvarious apprenticeships. Nationality Swedish Gender Male Occupation inventor, industrialist, and philanthropist “People require more in-depth discussions you can’t get away with a label anymore,” said Sen. Many senators in attendance represent states where Republican-led legislatures are pursuing abortion restrictions. Senators who attended Law’s presentation said he encouraged Republicans to be as specific as possible when they describe their positions on abortion, highlighting findings that he said could have a negative impact on elections. Todd Young, R-Ind., summarized Wednesday’s meeting as being focused on “pro-baby policies.”Īsked whether senators were encouraged to use a term other than “pro-life,” Young said his “pro-baby” descriptor “was just a term of my creation to demonstrate my concern for babies.” Eleven states, including Missouri, have enacted abortion bans with no exceptions for rape and incest. “They probably don’t.”Ībortion is now banned in 14 states, and several others have pursued restrictions. “You can’t assume that everybody knows what it means,” he added. Emily Elconin / Bloomberg via Getty Images file Anti-abortion demonstrators outside the Supreme Court on Dec. So if you’re going to talk about the issue, you need to be specific,” Hawley said Thursday. So the conversation was mostly oriented around how voters think of those labels, that they’ve shifted. “Many voters think means you’re for no exceptions in favor of abortion ever, ever, and ‘pro-choice’ now can mean any number of things. Josh Hawley, R-Mo., said the polling made it clear to him that more specificity is needed in talking about abortion. Kevin Cramer, R-N.D., said in an interview Thursday. “What intrigued me the most about the results was that ‘pro-choice’ and ‘pro-life’ means something different now, that people see being pro-life as being against all abortions. Work is continuing on the new app and it looks as though it’ll make its debut alongside Linux Mint 20.2 later this year.The polling, which NBC News has not independently reviewed, was made available to senators Wednesday by former McConnell aide Steven Law and showed that “pro-life” no longer resonated with voters. Will Nemo content search in Linux Mint 20.2 will help me? I can’t say until I try it, but I do know that being able to search for a keyword inside of a file has, on more than one occasion, helped me find something faster than it would’ve on other systems.įinally, don’t forget about Sticky, a sticky notes app for Linux Mint. Some of my most important ones (like templates for article thumbnails) have titles that either bear no relation to what’s actually inside, e.g., “aadadadad”, or come appended in a score of decreasingly helpful specificities, e.g., “new-document-final-draft-FINAL-New-draft-PROPER” □. files which are named a certain way and/or which contain particular words,” Mint say. In Nemo 5.0 you’ll be able to combine file search and content search, i.e. Until now you could only search for files. The next release soups up the Nemo file manager’s file search capabilities by enabling it to search file content as well as file name. The Linux Mint 20.2 beta is due for release sometime in June, ahead of the final, stable release of Linux mint 20.2 later thus year.īut bulk renaming aside, there’s another notable improvement set to ship in Linux Mint 20.2. Keen to try it? You don’t have to wait long. Mint’s Python-based Bulky looks as though it’s going to sit somewhere between the two option, offering relatively powerful renaming rules but exposed in a straightforward user interface. A number of apps catering to this task exist, ranging from command-line based batch renaming utilities to use-friendly GUI apps. Now, batch renaming files in Linux isn’t a task lacking options. Named Bulky, its aim is evident: let users bulk rename files in the Cinnamon and MATE desktops. Linux Mint devs have announced a new XApp (what Mint calls its homegrown apps) will feature in the upcoming Linux Mint 20.2 “Uma” release. Bulk renaming files in Linux Mint is about to get easier. Want more easy meal ideas? Check out our favorite slow-cooker recipes, our top quick dinner recipes, and our quick kid-friendly dinners too. Try our keto breakfast casserole, our cheesy croissant casserole, or our biscuits and gravy bake for ideas. Whether you’ve got a crowd to serve or are just looking to set yourself up for the whole week, we’ve got a great recipe for you. You can even enjoy casseroles for breakfast. One-Pot Chicken with Farro Is Packed with 44 Grams of Protein. Spinach Salad with Quinoa, Chicken & Fresh Berries. Try one of our many green bean casserole or sweet potato casserole recipes-do like we do, and make them more often than just for Thanksgiving. 20 Slow-Cooker Chicken Dinners You Can Prep in 30 Minutes or Less. They’re great for potlucks, since they’re pretty portable and are easy to reheat. Speaking of special occasions, casseroles fill out our holiday menus every year for good reason. Storecupboard one-pot Use simple storecupboard ingredients and frozen vegetables in our easy one-pot recipes, including rice dishes, curries and stews. If you’re looking for something a little more involved, try our broccoli rabe & Italian sausage lasagna, our eggplant Parm, or chicken pot pie casserole, or our zucchini lattice lasagna-they’re still super easy, but a few extra steps make them stand out. quick & easy One Pot Sausage Pasta The Best Ever Cheeseburger Weeknight Lemon Chicken Breasts Boiled Corn on the Cob Thai Coconut Curry Ramen Skillet Sun. These simple, affordable recipes use everything from tinned tomatoes to flour and sugar. Try our baked eggplant Parm, our chicken and rice casserole, our chicken pot pie noodle bake, or our turkey casserole for hearty, simple dinners. They’re hands-down the easiest weeknight dinner (on par with one-skillet meals), but can also be labors of love worthy of special occasions. Slice the tofu into cubes, drizzle with soy sauce, and gently toss the tofu in cornstarch before cooking in a skillet with hot oil until crispy and golden. Reviewers have used different soups, like cream of mushroom, cream of chicken, or chicken and herbs, and say the recipe is just as good. Check out our 69 casseroles for ideas-just assemble, sit back, and relaxxxx.Ĭasseroles can be enjoyed year-round, but there’s really something special about making one in the fall or winter. This casserole is a great way to sneak in some veggies because alongside the cheesy, creamy sauce and breadcrumbs, picky eaters wont even know the broccoli is there. We enjoy them from breakfast to dinner (and even dessert!) year-round (maybe a little less often when it’s hot out, but we’ve got some summertime ones here too). This super-easy weeknight dinner shows once and for all that braising isn't just for meat Spicy, tender sweet potatoes simmer in a delicious sauce with stewed carrot pieces and slightly crisp kale. Featuring some of Australias most popular dinner recipes including spaghetti bolognese. They’re simple to throw together can be filled with literally ALL your favorite meats, grains, and vegetables and can easily feed a crowd. Thats when this handy list of family dinner ideas comes to the rescue. There’s maybe nothing more comforting than a home-baked casserole.
Lens corrections for those currently supported by AfterShot let you correct a variety of lens distortions. Preview and purchase creative presets right in the app. A new camera profile updater keeps you informed of when new cameras are added. Similarly, a new plugin manager (offering both free and for-purchase plugins) lets you seek and load plugins and updates within the app. The app lets you browse, preview, and download both free and paid presets without leaving the program. When you need a new filter, you can consult the in-app Image Preset Library. Get rid of extraneous objects, facial blemishes, or other imperfections with the Blemish Remover tool. After selecting the tool, a black circle indicates the area and a red circle points to the sampled fix. The new tool’s circle, brush, polygon, and freehand tools ease portrait improvements and clean up dust, spots, smudges, and extraneous objects. The new Blemish Remover tool is specifically designed for facial touchups, but it can also work on a range of images to blot out all kinds of imperfections. The Highlight Recovery Range slider offers more refined control.Ī new algorithm is designed for more highlight recovery. A new algorithm that powers the update helps the app expose increased raw file data. Add image or text watermarks to all your photos to prevent theft.ĪfterShot Pro 3 also offers enhanced highlight recovery that helps you get more of the detail and tone from overexposed parts of your photos. However, it should be noted that there is only a very small amount of the compound formed in this process. You can check out the reason for the non-polarity of CS2. Few examples of nonpolar molecules are CS2, O2, etc. The dipole moment of nonpolar molecules is always equaled to zero. Elemental carbon and sulfide combine at very high temperatures to form CS2. And the geometrical shape of nonpolar molecules is always symmetric due to which the charge distribution on the atoms of these molecules is equally dispersed. The way this reaction occurs is actually very compatible with how you can see the molecule within the Lewis Dot Structure. In addition it will also go into the underlying reasons behind the determination of CS2s polarity.ĬS2 (carbon disulfide) can be formed naturally by volcanic eruptions or in marshes. The article will also discuss some of the ways in which CS2 differs from CO2. If you are interested in learning more about this subject, feel free to read this article on whether CS2 is polar or nonpolar. Chili sample analysis with confirming CS2 ion ratio 100:10 for m/z 76:78. One of the most popular reactions involving CS2 produces carbon tetrachloride (CCl4). The TG-624 column type is a mid-polarity column ideally suited for the. There also other uses for different chemical reactions involved in metallurgy and rubber production. These include many elements like phosphorus and sulfur and also larger compounds like fats, resins and rubber. One of these uses is as a solvent for other nonpolar compounds. There are only a limited number of uses for CS2 due to its pretty toxic properties. This concept is discussed further in our article on the polarity of CS2 which you can learn more about in the next section. This means that the compound is a liquid at standard temperature and pressure. The compound is slightly soluble within water and much more soluble in less polar compounds such as alcohol or even nonpolar compounds like benzene.ĭue to the stronger induced dipoles CS2 also has a greater melting and boiling point. As a result there can be more induced dipoles which increases the solubility of CS2. Due to the presence of large sulfide atoms over for comparison oxygen atoms in CO2 the molecule has a greater capacity for temporary london dispersion forces. The lewis dot structure for CS2 also predicts many of the properties of the molecule. This is a common feature for carbon as it is unlikely for this element in particular to have lone pair electrons. The combination of four electrons for the bonds and four electrons in lone pairs equals eight for sulfur while bonds supply eight electrons for the central carbon atom. As we've discussed before you could replace each bond with two electrons which would represent well how through the sharing of electrons each atom achieves a full octet. how many grams of cas is obtained if 152 g of cs2 is consumed in the reaction 11. This is the Lewis Dot Structure for Carbon Disulfide (CS2). Determine the heat of evaporation of carbon disulfide, cs2(l) - cs2(g) given the enthalpies of reaction below. Please feel free to edit this section to add missing information and complete it. Soft resetting specifically for a Shiny Pokémon is often called Shiny resetting. Soft resetting is faster than hard resetting because only the game and not the system needs to reboot, so it's often used due to the already time-consuming nature of attempting to generate a Pokémon with these specific qualities. Commonly, it is used to attempt to generate an in-game event Pokémon that is Shiny, or has particular IVs or Nature. This practice is widely considered useful, as rebooting the game (whether by soft resetting or hard resetting) will affect the values generated by the pseudorandom number generator. A "soft reset" contrasts to a "hard reset", which is restarting the game by rebooting the system itself.Ī soft reset can be performed at any time during gameplay, except while the game is saving. It involves holding certain buttons on the game system at the same time, which causes the game to return to the startup screen. Soft resetting (often shortened as SRing) is a feature found in the core series Pokémon games, as well as several other Pokémon games. For the Pokémon Trading Card Game rarity, see Ultra rare card (TCG). For the move commonly shortened to "SR", see Stealth Rock (move). Pokémon Brilliant Diamond and Shining Pearl.First are Sky Battles, which can only be participated in by Flying-type Pokémon, and Horde Encounters which are wild Pokémon encounters where you face off against up to 5 Pokémon at once. Like previous new generations, Pokémon X & Y brings several new forms of battling. First, you can use Pokémon Bank to store up to 3,000 Pokémon on the cloud, and you can use the Poké Transporter to transfer Pokémon from Black, White, Black 2 & White 2. Pokémon X & Y have compatibility with two bits of Nintendo 3DS download software. This game also introduces the idea of Trainer Customisation, allowing you to not only pick your trainer's hair colour and skintone from three options, but to completely customise your trainer's outfit and accessories With this, you have the ability to increase your pokémon's Effort Values through a scheme of mini-games and various other features. The game also makes training a Pokémon's Effort Values easier through a mini-game system known as Super Training. There are a variety of new features involved including being able to ride certain Pokémon within certain areas. In the game, you start off as a trainer, being able to customise the appearance between three different options for each of the genders. The games are set within the Kalos region, a large region which has a Regional Pokédex split into three parts, Central, Coastal and Mountain. You even get given a Kanto starter Pokémon in order to get their Mega Evolution. These give certain Pokémon a temporary evolution in battle to a stronger, never-seen-before, appearance with increased stats, changed abilities and sometimes even different types. In addition to new Pokémon and a new type, Pokémon X & Y introduce a whole new feature to Pokémon, Mega Evolutions. It also is the first game since Gold & Silver to introduce a new type, the Fairy-type The addition of the new Pokémon takes the number of Pokémon over to well above 700. It introduces a variety of new Pokémon including Chespin, Fennekin and Froakie, the new starter Pokémon and Pokémon X stars the legendary Pokémon Xerneas while Pokémon Y features the Pokémon Yveltal. The world also is completely 3D, while keeping grid based movement. These games are the first to include a real 3D world and 3D battles, utilising 3D models in amazing battle environments. Pokémon X & Pokémon Y are the first Generation VI Pokémon games, coming for the Nintendo 3DS worldwide in October 2013
One to two-mile hikes with a ranger into the old growth coniferous forest or aspen parkland provide opportunities for students to learn about photosynthesis, nutrient cycling, succession, disturbance, forest ecology, wild flowers, and American Indian uses of both plants and animals.
|
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |